PhD Graduate in Virology Unpacks COVID-19 Dynamics in South Africa

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Dr Upasana Ramphal has graduated with a Doctor of Philosophy (PhD) in Virology from the University of KwaZulu-Natal (UKZN), producing ground-breaking research that sheds light on how COVID-19 spread and evolved across South Africa.

Her study, ‘Unravelling the Genomic and Epidemiological Dynamics of SARS-CoV-2 in South Africa,’ was supervised by world-renowned bioinformatician and infectious disease expert Professor Tulio de Oliveira, known for his pioneering work in genomic surveillance, pandemic preparedness and capacity building in Africa. Ramphal’s study offers critical insights into the role of genomic surveillance in managing infectious disease outbreaks.

“This work highlights how genomic surveillance supports better decision-making in public health,” said Ramphal. “It strengthens disease monitoring systems and contributes to more effective responses to future pandemics, both in South Africa and globally.”

Her study integrated multiple dimensions of pandemic science, including platform comparison, provincial surveillance trends and South Africa’s contribution to global data sharing into a single body of work.

This comprehensive approach provided new insights into both the scientific and public health value of genomic surveillance.

Reflecting on her achievement, Ramphal described the PhD as a deeply personal milestone.

“I am immensely proud of earning my PhD, as it represents a truly momentous personal achievement. It reflects years of dedication and perseverance,” she said. “The title ‘Dr’ carries the weight of a thousand sleepless nights and a journey defined by resilience, sacrifice and unwavering determination.”

Originally from Ladysmith and raised in Durban, Ramphal’s passion for science began at a young age. Her academic journey spanned a BSc in Microbiology, a BTech in Biotechnology, a Master’s degree in Medical Science, and now a PhD. This marked a historic achievement as the first in her family in four generations to attain a doctoral degree.

Her career has been driven by a deep curiosity about infectious diseases and a desire to make a meaningful societal impact.

During the height of the COVID-19 pandemic, Ramphal played a key role in supporting South Africa’s testing response, contributing to the establishment of laboratories and training teams to conduct SARS-CoV-2 testing across multiple sites.

A registered Professional Scientist with the South African Council for Natural Scientific Professions (SACNASP), Ramphal brings over a decade of experience in pharmaceutical manufacturing and regulatory compliance.

She is a strong advocate for ethics and data integrity in science - principles that have guided both her research and professional practice.

Currently working as a medical writer for a leading international medical communications company, Ramphal continues to contribute to global health knowledge through scientific communication.

Despite the challenges of her PhD journey, she credits her resilience and focus with seeing her through. “I approached challenges directly and used each experience as an opportunity to grow. It strengthened my resolve and determination to achieve meaningful results,” she said.

Beyond her professional achievements, Ramphal enjoys reading, spending time with family and friends, and reconnecting with nature, moments she values as essential for reflection and balance.

Words: MaryAnn Francis

Photograph: Sethu Dlamini