Unlocking New Frontiers in Peptide Synthesis

BY: .

Dr Sikabwe Noki’s path to earning a PhD in Pharmaceutical Chemistry is a story of passion, perseverance and ground-breaking research. 

Born and raised in Uvira, South-Kivu in the Democratic Republic of the Congo, Noki’s interest in chemistry was ignited during his high school years at Elimu Secondary School where his teacher Mr Fabien Mabiala saw chemistry not just as a subject, but as a tool capable of transforming lives. 

Growing up in a region where access to essential medicines was scarce, he witnessed first-hand the devastating impact of treatable diseases left unchecked. These experiences sparked a curiosity about how medicines were created and who was responsible for their development. A visit to an undergraduate chemistry laboratory solidified his fascination with organic and natural product chemistry, laying the foundation for his future in pharmaceutical research. 

As his academic journey progressed, Noki developed a keen interest in peptide chemistry. During his master’s studies, he was introduced to the synthesis of Teixobactin derivatives, a novel cyclic peptide antibiotic. This work fuelled his determination to contribute to the fight against antibiotic resistance, ultimately leading him to pursue a PhD. His research delved deeper into antimicrobial peptide synthesis, an area crucial for developing new therapeutic solutions. 

Noki’s PhD research focused on advancing Solid-Phase Peptide Synthesis (SPPS), the principal method for peptide production in both research and industry. Over the years, SPPS has undergone significant innovations, particularly in the development of “safety-catch” linkers and protecting groups that improve synthesis efficiency and peptide stability. 

A key aspect of his work was the introduction of novel safety-catch protecting groups, such as Msz, which enhance peptide synthesis by preventing unwanted side reactions. His research also led to the development of new amino acid derivatives with advanced side-chain protection, facilitating the synthesis of complex and biologically significant peptides. These discoveries were carried out in collaboration with Iris Biotech GmbH, where one of his amino acids, Fmoc-Ser (Msbh)-OH, was featured as their product of the month. 

Additionally, Noki designed and characterised a novel base-labile safety-catch linker, named “Noki Linker”, aimed at improving SPPS efficiency. This project, developed in collaboration with AAPPTEC, LLC, was patented under US patent law, marking a significant milestone in his research career. 

Noki is currently a postdoctoral research fellow in Chemistry at the UKZN Peptide Science Laboratory. In this role, he continues to expand his research in peptide-based therapeutics and drug discovery. 

Looking ahead, he envisions applying his expertise in either academia or industry. In academia, he aims to push the boundaries of peptide synthesis while mentoring future scientists and collaborating on interdisciplinary projects. In industry, he hopes to contribute to research and development, particularly in peptide-based drug design and biomaterials. Regardless of the path he takes, his goal remains the same - to drive meaningful scientific advancements and address real-world healthcare challenges. 

Outside of his research, Noki enjoys activities that reflect his curiosity and problem-solving nature. ‘I enjoy cooking, which is similar to chemistry with tastier results.’ He also enjoys jogging, swimming, and exploring new places, which provide a refreshing break from his rigorous scientific endeavours. 

Noki attributes much of his success to his supervisors, Professor Beatriz G de La Torre and Professor Fernando Albericio. ‘Their guidance, encouragement and support have been instrumental in helping me navigate the challenges of my PhD journey.’ 

Words: MaryAnn Francis

Photograph: Sethu Dlamini