Dr Abdul Rashid Issahaku celebrates graduating with a PhD in Pharmaceutical Chemistry.PhD Study Identifies Potential Anticancer Drugs
Dr Abdul Rashid Issahaku earned his PhD in Pharmaceutical Chemistry for his study on a Computational Exploration of Molecular Determinants in the Inhibition of Selected Critical Oncogenic Targets in Cancer Therapy.
Supervised by Professor Mahmoud Soliman, Issahaku employed computer-aided drug design (CADD) techniques to probe the molecular factors involved in inhibiting crucial oncogenic targets in cancer therapy, focusing on Kirsten rat sarcoma (KRAS), Bruton’s tyrosine kinase (BTK), and Methyltransferase-like 3 (METTL3) proteins.
He noted that, ‘The findings serve as a roadmap for the identification of potential anticancer drugs derived from natural compounds found in South Africa.’
His study offers invaluable insights into the atomic and structural characteristics of KRAS, BTK, and METTL3 proteins that contribute to their resistance against drug inhibition. The findings pave the way for the development of affordable, less toxic anticancer drugs.
‘This achievement has solidified my long-standing aspiration to become a respected researcher in the field of cancer,’ said Issahaku. However, his research journey was not without its challenges. ‘The initial unexpected outcomes in the early stages of my research were both frustrating and disheartening. However, with the guidance and encouragement of my colleagues, I managed to overcome these obstacles.’
He praised UKZN for its unwavering support and for providing him with abundant resources that enabled him to accomplish his research goals: ‘The University offered me numerous opportunities in the form of workshops and seminars, which greatly contributed to my personal and professional growth.’
Issahaku’s professional journey began as a medical laboratory scientist in Ghana, where he worked in a private setting for three years before transitioning to the field of pharmaceutical chemistry research. He also holds a master’s degree in Health Sciences (cum laude), specialising in Pharmaceutical Chemistry. In his leisure time, he enjoys literature and engaging in philosophical discussions.
Words: Nombuso Dlamini
Photograph: Sethu Dlamini